USAID DEC
AID cooperative agreement no. HRN-6001-A-00-3019-00 with the University of Maryland at Baltimore (UMAB) to support malaria vaccine research and development
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AID cooperative agreement no. HRN-6001-A-00-3019-00 with the University of Maryland at Baltimore (UMAB) to support malaria vaccine research and development
Grant is provided under the Malaria Vaccine Development project to the University of Maryland at Baltimore to conduct research to prepare candidate vaccines against malaria due to Plasmodium falciparum.
1993
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Abstract
The vaccines will consist of genetically engineered attenuated Salmonella typhi oral vaccine strain CVD 908 expressing complete circumsporozoite protein (CSP) or a fusion peptide consisting of the immunodominant B- and T-lymphocyte epitopes of CSP. If successful, this will be regarded as an initial step towards the construction (under future funding) of a multivalent vaccine that will incorporate additional relevant antigens of the sporozoite, exoerythrocytic, and asexual erythrocytic stages of P. falciparum.
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