AID grant no. LAG-4200-G-00-3048-00 to the World Bank/Consultative Group on International Agricultural Research (CGIAR) for assistance to the Vavilov Institute of Plant Industry in support of `Proposed protocol for quarantine field test of vaccinia virus double recombinant vaccine for rinderpest in Kenya`

Rinderpest is the single most important disease of livestock in developing countries of Africa and Asia. This quarantine field test will gather information over a one year period on the efficacy and safety of VVDRVR for vaccination against rinderpest. Properly used, this vaccine may rid the world of rinderpest within a decade. In the current trial, VVDRVR will be administered to cattle by intradermal injection and scarification in a P3 isolation facility. Cattle will be kept under strict quarantine for 30 days after vaccination and then transferred to a fenced pasture. Immunological and challenge studies will be conducted in a P3 facility for 1 year. After completion of the challenge study, the animals will be euthanized and their carcasses incinerated.