Research final project report

To develop an alternative treatment regimen against these strains, the evaluation of sulfalene-trimethorprim and sulphormethoxine-pyrimethamine was accomplished which showed no significant difference between the two treatment regimens. Subsequent studies of sulphor-methoxine-pyrimethamine showed that cure rate was at least 90% and that primaquine was required to counter the demonstrated lack of sporontocidal effect of the combination. Based on these results, the MNEP adopted the use of sulphor-methoxine-pyrimethamine as the standard treatment for falciparum malaria in Thailand. The evaluation of alternative treatment regimens against falciparum strains "resistant" to sulphor-methoxine-pyrimethamine based on quinine alone or in combination with other drugs was also accomplished. The results showed possible quinine resistance (to seven days treatment) and suggested that quinine in combination with tetracycline may provide additive effect.